造影超音波を用いた肝細胞癌に対するサイバーナイフ治療前後の血流評価
済生会横浜市東部病院
塩澤一恵ほか
肝細胞癌に対してサイバーナイフ治療前後にソナゾイド造影超音波を施行した。症例により時期の差はみられたが、治療後に腫瘍内部の染影低下を認め、腫瘍周囲肝実質は血管相で強い染影、後血管相で同部はdefectを呈した。造影超音波による腫瘍および腫瘍周囲肝実質の血流動態の評価は、低侵襲かつ比較的早い段階でのサイバーナイフの治療効果判定に応用できる可能性が示唆された。
To evaluate the change of hemodynamics in hepatocellular carcinoma (HCC) before and after CyberKnife using contrast-enhanced ultrasonography (CEUS) with Sonazoid. Four HCC patients enrolled inthis study. The enhancement of tumor and liver around tumor in the vascular phase, and the presenceor absence of defect in the post-vascular phase were assessed. However, the onsets of change inthese CEUS findings varies by each case, in the case of early hemodynamic response, CEUS showedthe strong enhancement of the liver around tumor two weeks after the therapy, and defect appearanceof the liver around tumor and the hypoenhancement of the tumor in the post-vascular phase four weeksafter the therapy. CEUS were suggested to be useful for evaluating early responses to Cyber Knife.
